Objectives This review aims to highlight the advantages and safety of oxygen-ozone\udtherapy (OOT) and to suggest ways to enhance its acceptance.\udKey findings The treatment of a herniated disk by injecting a gaseous oxygen-ozone\udmixture inside the nucleus pulposus is a great clinical success. However, the use of\udOOT lags for a number of reasons, including lack of standardization, the need for\udnumerous treatments, lack of knowledge and even denial. Anecdotally, several\udmillion treatments by OOT have been performed worldwide indicating its usefulness,\udmainly in peripheral arterial diseases and age-related macular degeneration.\udThe scepticism that accompanies the systemic use of ozone can only be overcome by\uddemonstrating the validity of OOT in controlled and randomized clinical trials.\udCheaper and quicker methods, such as ozonating physiological saline with successive\udinfusion as well as ozone rectal insufflations, are becoming popular, however,\udsuch alternative procedures are erratic, unstable and liable to be toxic, with deleterious\udconsequences, and are likely to discredit the beneficial use of ozone.\udSummary The approval of ozone in terms of both therapeutic efficacy and safety\udwill depend on the results achieved by authoritative clinical trials.
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